New α-galactosidase-inhibiting aminohydroxycyclopentanes

beta-Galactosidase-inhibiting new isoflavonoids produced by actinomycetes.

Six isoflavonoids having beta-galactosidase inhibiting activity were isolated from the culture filtrate of Streptomyces xanthophaeus. Their structures were determined by spectral analyses to be daidzein, daidzein 7-alpha-L-rhamnoside, daidzein 4',7-di-alpha-L-rhamnoside, genistein, genistein 7-alpha-L-rhamnoside and genistein 4',7-di-alpha-L-rhamnoside.

Release of β-galactosidase from poloxamine/α-cyclodextrin hydrogels

All mammals lose their ability to produce lactase (β-galactosidase), the enzyme that cleaves lactose into galactose and glucose, after weaning. The prevalence of lactase deficiency (LD) spans from 2 to 15% among northern Europeans, to nearly 100% among Asians. Following lactose consumption, people with LD often experience gastrointestinal symptoms such as abdominal pain, bowel distension, cramp...

The structure of Saccharomyces cerevisiae α-galactosidase 1 STRUCTURAL ANALYSIS OF SACCHAROMYCES CEREVISIAE α-GALACTOSIDASE AND ITS COMPLEXES WITH NATURAL SUBSTRATES REVEALS NEW INSIGHTS INTO SUBSTRATE SPECIFICITY OF GH27 GLYCOSIDASES

Α-glucosidase and Chymotrypsin Inhibiting Lignans from Commiphora Mukul

Phytochemical investigation of the whole plant of Commiphora mukul Engl. resulted in the isolation of two lignans, epiexcelsin (1) and 5′-demethoxyepiexcelsin (2) which are reported for the first time from this species. The structure elucidation of the isolated compounds was based on 1D and 2DNMR analysis and by the comparison with the published data. The lignans 1 and 2 showed significant inhi...

Plasma mutant α-galactosidase A protein and globotriaosylsphingosine level in Fabry disease

Fabry disease is an X-linked genetic disorder characterized by deficient activity of α-galactosidase A (GLA) and accumulation of glycolipids, and various GLA gene mutations lead to a wide range of clinical phenotypes from the classic form to the later-onset one. To investigate the biochemical heterogeneity and elucidate the basis of the disease using available clinical samples, we measured GLA ...